The Institute of Pharmaceutical Innovation

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Dr Wendy Louise Hulse
Biopharmaceutical Formulation Scientist
  • Telephone: 01274236156
  • Email: w.l.hulse1@brad.ac.uk

Member of The Royal Society of Chemistry

Research interests

*Polymorphism

*Co-crystals

*Crystal engineering

*Nanometric molecular solid

Current research projects

Development of a novel capillary based UV detector for potential size and concentration analysis of therapeutic protein aggregation.
Development of methods and applications of the instrument and its coupling to HPLC/CE systems as a secondary detector.
Comparison of the methods developed to existing particle sizing methods including light scattering and HPLC/CE.

Formulation and analysis of therapeutic protein dosage forms with emphasis on solid state stabilisation of proteins for potential pulmonary delivery. Development of microfluidic cells for the production of respirable sized protein crystals.

The use of DVS and thermal techniques for the analysis of pharmaceutically relevant excipients, APIs and therapeutic proteins.

Publications

Do co-spray dried excipients offer better lysozyme stabilisation than single excipients? W.l.Hulse, R.T.Forbes, M.C.Bonner (2008). Eur. J. Pharm.Sci., 33, 294-305.

The impact of low level inorganic impurities on key physicochemical properties of paracetamol. W.L.Hulse, M. De Matas, I.M.Grimsey (2008). Int. J.Pharm., 349, 61-65.

The characterisation and comparison of spray dried mannitol samples. W.L.Hulse, R.T.Forbes, M.C.Bonner (2009) Drug. Dev. Ind. Pharm. Drug. Dev. Ind. Pharm., 35:6, 712-718.

Invited Presentations

EUFEPS, Nice (2009). Novel instrumentation to gain insight into the aggregation state of proteins by Taylor dispersion analysis: a comparison with dynamic light scattering