The Institute of Pharmaceutical Innovation

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Prof. Anant Paradkar, MPharm (Pharmaceutics), PhD
Professor of Pharmaceutical Engineering, Interdisciplinary Chair in Pharmaceutical Engineering Science
  • Telephone: +44-1274-233900
  • Email: A.Paradkar1@Bradford.ac.uk

Research Interests include:

*Particle Engineering

*Amorphous State Stabilization

*Lyotropic Liquid Crystals

*Formulation Development and Herbal Formulations

*Hot Melt Extrusion

Current Research Projects

1. Particle Engineering
2. Development of novel applications of Hot melt extrusion technology
3. Liquid Crystalline Systems
4. Phytopharmaceutical and Nutraceutical Formulations
5. Shear and extensional rheology of polymers and liquid crystalline systems

1. Particle Engineering

I have been working on various aspects of particle engineering; after starting with spherical crystallization, modified it as crystallo-co-agglomeration which is being now attempted for design of deformable matrices. For processing of low Tg drugs we are exploiting melt sonocrystallization. Goal is to design hollow and porous particles or aggregates of particles for inhalation drug delivery.
Currently, I am working with Professor Peter York on development of engineered drug and excipient particles using supercritical fluid technology and sonocrystallization. Significant improvement has been shown by lactose and salbutamol sulphate particles obtained by sonocrystallization. We are implementing Royal Society Funded project on supercritical fluid technology with Central Drug Research Institute, India.
Sonocrystallized lactose with drug on the surface


Sonocrystallized salbutamol particles

Formation and stabilization of amorphous drug is another important area where I am exploring applications of lipids as stabilizers of amorphous form on the shelf as well as during processing. The attempts are also being made to overcome problems in spray drying of low Tg drugs.

2. Development of novel applications of Hot melt extrusion technology

I am working as core member of a strong interdisciplinary research team across IPI and Interdisciplinary Research Centre (IRC) in Polymer Science and Technology. We are working on different applications of hot melt extrusion ranging from solubility improvement, formulation design and crystal engineering. A proof of concept project has been funded by regional funding agency for novel application development of hot melt extrusion.

3. Liquid Crystalline Systems

In the area of lyotropic liquid crystalline systems we are focusing on factors affecting mesophases (especially cubic and lamellar phases) and the performance of the delivery system. Attempts are also being made to design liquid crystal precursors. Role of liquid crystalline phases in novel drug delivery systems for floating drug delivery, protein stabilization and self emulsification is being investigated.

4. Phytopharmaceutical and Nutraceutical Formulations

Tumeric


Curcumin

Novel formulations of phytopharmaceuticals have been designed. The basic concept is application of modern concepts in pharmaceutics to the particle engineering and formulation of phytopharmaceuticals. Spray dried solid dispersion of curcumin, curcumin injection are some important formulation which have been developed and being investigated in cell lines.
Apiceuticals (products from honey bees) is also being explored for novel applications in association with an international consortium.

5. Shear and extensional rheology of polymers and liquid crystalline systems

Projects have been undertaken for development of applications and analysis of mechanisms for performance of polymers through rheological characterization. Shear and extensional rheology has been investigated. Now focus is being the study of surface instabilities, wall slip, die swell and process control during melt extrusion. The porous systems of polymers were generated and are being investigated further.


Surface instabilities and Porous nature of Hydroxypropyl Cellulose extrudate


Dr. Ravindra Dhumal
Ravindra is Postdoctoral Research Assistant, has three years industrial experience and is now working with an interdisciplinary team at IPI and IRC. His area of research is development of novel applications of HME in crystal engineering. He is also investigating novel plasticizers for pharmaceutical formulations.

Memberships:
Association of American Pharmaceutical Scientists (AAPS)

List of publications

Paradkar, A., Kelly, A., Coates, P., York, P.
Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry
(2009) Journal of Pharmaceutical and Biomedical Analysis, . Article in Press.

Dhumal, R.S., Biradar, S.V., Paradkar, A.R., York, P.
Particle engineering using sonocrystallization: Salbutamol sulphate for pulmonary delivery
(2008) International Journal of Pharmaceutics, . Article in Press.

Dhumal, R.S., Biradar, S.V., Paradkar, A.R., York, P.
Ultrasound assisted engineering of lactose crystals
(2008) Pharmaceutical Research, 25 (12), pp. 2835-2844.

Dhumal, R.S., Biradar, S.V., Yamamura, S., Paradkar, A.R., York, P.
Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability
(2008) European Journal of Pharmaceutics and Biopharmaceutics, 70 (1), pp. 109-115.

Shimpi, S., Mahadik, K., Takada, K., Paradkar, A.
Application of polyglycolized glycerides in protection of amorphous form of etoricoxib during compression
(2007) Chemical and Pharmaceutical Bulletin, 55 (10), pp. 1448-1451.

Shah, M.H., Paradkar, A.
Effect of HLB of additives on the properties and drug release from the glyceryl monooleate matrices
(2007) European Journal of Pharmaceutics and Biopharmaceutics, 67 (1), pp. 166-174.

Maheshwari, M., Paradkar, A., Yamamura, S., Kadam, S.
Preparation and characterization of Pluronic-colloidal silicon dioxide composite particles as liquid crystal precursor
(2006) AAPS PharmSciTech, 7 (4), art. no. 92, pp. E1-E7.

Shah, M.H., Biradar, S.V., Paradkar, A.R.
Spray dried glyceryl monooleate-magnesium trisilicate dry powder as cubic phase precursor
(2006) International Journal of Pharmaceutics, 323 (1-2), pp. 18-26.

Pokharkar, V.B., Mandpe, L.P., Padamwar, M.N., Ambike, A.A., Mahadik, K.R., Paradkar, A.
Development, characterization and stabilization of amorphous form of a low Tg drug
(2006) Powder Technology, 167 (1), pp. 20-25.

Chauhan, B., Shimpi, S., Paradkar, A.
Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique.
(2005) AAPS PharmSciTech [electronic resource]., 6 (3), pp. E405-412.

Ambike, A.A., Mahadik, K.R., Paradkar, A.
Physico-chemical characterization and stability study of glassy simvastatin
(2005) Drug Development and Industrial Pharmacy, 31 (9), pp. 895-899.

Chauhan, B., Shimpi, S., Mahadik, K.R., Paradkar, A.
Preparation and evaluation of floating risedronate sodium-gelucire® 43/01 formulations
(2005) Drug Development and Industrial Pharmacy, 31 (9), pp. 851-860.

Chauhan, B., Shimpi, S., Paradkar, A.
Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique
(2005) European Journal of Pharmaceutical Sciences, 26 (2), pp. 219-230.

Shimpi, S.L., Chauhan, B., Mahadik, K.R., Paradkar, A.
Stabilization and improved in vivo performance of amorphous etoricoxib using Gelucire 50/13
(2005) Pharmaceutical Research, 22 (10), pp. 1727-1734.

Ambike, A.A., Mahadik, K.R., Paradkar, A.
Spray-dried amorphous solid dispersions of simvastatin, a low Tg drug: In Vitro and in Vivo evaluations
(2005) Pharmaceutical Research, 22 (6), pp. 990-998.

Shah, M.H., Paradkar, A.
Cubic liquid crystalline glyceryl monooleate matrices for oral delivery of enzyme
(2005) International Journal of Pharmaceutics, 294 (1-2), pp. 161-171.

Ambike, A.A., Mahadik, K.R., Paradkar, A.
Stability study of amorphous valdecoxib
(2004) International Journal of Pharmaceutics, 282 (1-2), pp. 151-162.

Kumar M., K., Shah, M.H., Ketkar, A., Mahadik, K.R., Paradkar, A.
Effect of drug solubility and different excipients on floating behaviour and release from glyceryl monooleate matrices
(2004) International Journal of Pharmaceutics, 272 (1-2), pp. 151-160.

Paradkar, A., Ambike, A.A., Jadhav, B.K., Mahadik, K.R.
Characterization of curcumin-PVP solid dispersion obtained by spray drying
(2004) International Journal of Pharmaceutics, 271 (1-2), pp. 281-286.

Maheshwari, M., Ketkar, A.R., Chauhan, B., Patil, V.B., Paradkar, A.R.
Preparation and characterization of ibuprofen-cetyl alcohol beads by melt solidification technique: Effect of variables
(2003) International Journal of Pharmaceutics, 261 (1-2), pp. 57-67.

Paradkar, A.R., Pawar, A.P., Chordiya, J.K., Patil, V.B., Ketkar, A.R.
Spherical crystallization of celecoxib
(2002) Drug Development and Industrial Pharmacy, 28 (10), pp. 1213-1220.