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Jump to Services NavigationStable Amorphous Formulations
Thermodynamically, the amorphous state shows the greatest solubility, however it has also the largest propensity to re-crystallise on storage. Further, the lack of a crystal lattice can cause increased degradation. Amorphous forms can be readily stabilized by producing a molecular /solid dispersion, hot melt extrusion technology is a simple, fast and effective method of preparing amorphous materials as solid dispersions.
The IPI CIC offers a phase approach to identifying and preparing the most stable amorphous of your active.
Phase 1-Solid dispersion screen- using a range of polymers
Phase 2-Small scale hot melt extrusion trial and 30 day stability study
Phase-3 Preparation of a formulated product for preclinical studies
