Services
Jump to Services NavigationPharmaceutical and Chemical Analysis - Spectroscopic and Imaging Analysis
Raman Spectroscopy
Heritage of UoB here re-Raman Spectroscopy
Raman Spectroscopy aids in the determination of the chemical structure of a sample and identifies the compounds present by measuring molecular vibrations. It is an excellent technique for qualitative analysis but can also be used for semi-quantitative and quantitative analysis. Its ability to provide a “chemical fingerprint” of a pharmaceutical compound makes it a powerful analytical tool for determining molecular composition and structure, identifying polymorphs and assessing other physico-chemical properties that are important for understanding predicting and controlling drug product performance.
Pharmaceutical Raman Imaging
Analytical scientists at the PI CIC have extensive knowledge and experience of using Raman
Spectroscopy to evaluate the physico-chemical properties of pharmaceutical materials. Using
Raman mapping techniques the PI CIC have previously studied
Differences in physical form in a pharmaceutical formulation crystalline vs amorphous
The distribution of one or more active ingredients in a tablet
Determined the particle size of one or more actives in a tablet
Raman Spectroscopy facilities
Renishaw InVia Raman Microscope (785/633nm laser excitation)
Bruker IFS FT-Raman (1064 nm)
Renishaw RIAS portable instrument with fibre optic probe
Nuclear Magnetic Resonance Spectroscopy (NMR)
NMR spectroscopy at Bradford covers both solid and solution state
facilities. NMR provides information on chemical speciation, molecular
interactions, molecular structure in solution and material structure in the solid.
Bradford’s high fieldfacilities enable high resolution multinuclear studies with
low levels of analyte and complex mixtures.
Key areas of expertise include:
Cancer drug structure elucidation and drug-target evaluation
Biochemical speciation of protein, lipids and carbohydrates
Drug metabolite characterisation in biological matrices
Chemical reaction monitoring
Natural product structure elucidation including identification of drug
candidates
Solid state polymorph characterisation
NMR Facilities
Multi-nuclear JEOL ECA 600 FT NMR Spectrometer
Nalorac Inverse Fg 1H-{13C, 15N} High Sensitivity 5 mm probe
Variable Temperature Facility (-100 °C to +200 °C)
Triple Resonance Facilities
Multi-nuclear Bruker Avance 400 FT NMR Spectrometer Equipped for routine 1H, 13C, 19F and 31P experiments QNP 5mm variable temperature probe Equipped for 1D and 2D NMR experiments including 1H-X nucleus correlation experiments (HMBC and HMQC)
Recent work
Multinuclear (1H/13C/19F/15N) and multidimensional (COSY, HMBC, HMQC) structure elucidation of oxidative impurities in a pharmaceutical API product
Graft efficiency of novel polymers from reactive extrusion
Method development for determination of solubility of respiratory drugs under elevated pressure
Lipid profiling of biological membrane materials
Related Services
- Preformulation Package
- Solid State Screening - Salt /Co-crystal Screen
- Solid State Screening - Polymorph Screen
- Solid State Screening - Solid Dispersion Screen
- Solid State Screening - Super critical fluid (SCF) crystallisation screen
- Pharmaceutical and Chemical Analysis - Chromatographic Analysis
- Pharmaceutical and Chemical Analysis - Solid Form Analysis
- Pharmaceutical and Chemical Analysis - Elemental Analysis
- Pharmaceutical and Chemical Analysis - Thermal Analysis
- Pharmaceutical and Chemical Analysis - Particle Size Analysis and Surface Characterisation
