Services
Jump to Services NavigationPharmaceutical and Chemical Analysis - Elemental Analysis
At the Pharmaceutical Innovation CIC we have a range of instruments capable of
determining the elemental composition and detecting trace elements in your
samples. We can offer X-ray Fluorescence (XRF), Inductively Coupled Plasma Mass
Spectrometry (ICP-MS) and Scanning Electron Microscope Energy Dispersive X-ray
Spectroscopy (SEM-EDX) analyses as well as our comprehensive expertise with this equipment and techniques.
SEM-EDX (Scanning Electron Microscope Energy Dispersive X-ray
Spectroscopy)SEM provides a highly detailed topographical view of a material at high
magnifications. When combined with EDX it can be used to identify the
elemental chemical composition of a specimen or small area of
interest on a sample. The x-ray mapping feature also allows for tracing
the occurrence (mapping) of elements within a specimen.
Recent Applications:
SEM-EDX analysis was used to detect trace levels of metal contamination in a
pharmaceutical product
ICP-MS was used to determine trace levels of metals in an API
ICP-MS (Inductively Coupled Plasma Mass Spectrometry)
ICP-MS is a very powerful tool for analysing trace and ultra trace elements, it has become the technique
of choice in many analytical labs by providing accurate and precise measurements at low limits of
detection.
XRF (X-ray Fluorescence analysis) In X-ray fluorescence analysis a material is exposed to X-rays of high energy and as the X-ray strikes an
atom energy is absorbed, if this is high enough, a core electron is ejected and replaced by an electron
from an outer shell this give rise to the emission of an X-ray of fixed energy that is detected by a
fluorescence detector. This energy to eject a core electron is specific to each element.
XRF is a technique for elemental analysis that gives highly accurate determinations for major elements
and a broad elemental survey of the sample composition without standards.
Recent Applications:
SEM-EDX analysis was used to detect trace levels of metal contamination in a pharmaceutical product
ICP-MS was used to determine trace levels of metals in an API
Related Services
- Preformulation Package
- Solid State Screening - Salt /Co-crystal Screen
- Solid State Screening - Polymorph Screen
- Solid State Screening - Solid Dispersion Screen
- Solid State Screening - Super critical fluid (SCF) crystallisation screen
- Pharmaceutical and Chemical Analysis - Chromatographic Analysis
- Pharmaceutical and Chemical Analysis - Solid Form Analysis
- Pharmaceutical and Chemical Analysis - Spectroscopic and Imaging Analysis
- Pharmaceutical and Chemical Analysis - Thermal Analysis
- Pharmaceutical and Chemical Analysis - Particle Size Analysis and Surface Characterisation
