The Institute of Pharmaceutical Innovation

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Molecular pharmaceutics

Expertise centres on the definition and description of the molecular detail of pharmaceutical materials, providing the basis for predicting properties and processing characteristics important in the design of new drug delivery systems. These activities are complemented by research into crystal nucleation, the controlled and directed crystallisation of pharmaceutical materials and characterisation of particulate properties. Other formulation studies for poorly-water soluble drugs, such as solid dispersion generation, also link to the molecular description of the drug. More recent research includes the engineering of therapeutic nanoparticles.

The formulation and stabilisation of protein drugs for conventional and inhaled routes forms part of the expanding research theme for the group. Research themes include investigation of the mechanism and efficacy of stabilising excipients for peptide and protein delivery both in solution and solid-state, the use of alternative drying technologies (supercritical fluids, spray-drying), and protein crystallisation.