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Dr Michael Bonner
Lecturer in Pharmaceutical Technology
  • Telephone: +44 (0) 1274 233219
  • Email: m.bonner@bradford.ac.uk

My main area of interest is in biopharmaceutics, with special emphasis on drugs delivered via the topical or transdermal routes. The skin is an attractive option to the pharmaceutical formulator as it is the largest organ of the body, is readily accessible and absorption of actives through it are not subjected to hepatic first-pass metabolism. However, the outermost layer of the skin – the stratum corneum (SC) has evolved to prevent a formidable barrier to noxious substances and to prevent loss of water from the body.
Hence I have an interest in methods of circumventing the SC barrier through chemical and electrical methods in order to maximise the bioavailability of drugs via the skin, and potentially to promote delivery of challenging molecules such as water-soluble peptides via this route. In addition I have been examining the potential for drug delivery by the shunt route in skin (a combination of hair follicles and sweat glands). I have also an interest in augmenting the skin barrier for the prevention of water loss.
In the promulgation of this research I have spoken at a variety of national and international meetings including a prestigious Gordon Conference, chaired a session on transdermal therapies at the American Association of Pharmaceutical Scientists and fostered collaborative links with the University of Strathclyde and the University of Queensland in Brisbane where I have spent 6 months as a visiting researcher. In addition, I have acted as an adviser to the Therapeutic Goods Administration (the OTC Medicines regulator) in Australia (2007) on a product licence application for a topical therapy.—————————————————————————
Recent publications

*The influence of drug partition coefficient on follicular penetration: In vitro human skin studies
Frum, Y, Bonner, M. C., Eccleston, G. M., Meidan, V. M.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 30 (3-4): 280-287 MAR 2007

Book chapters

*Electrical enhancement of Transdermal Delivery of Ultradeformable Liposomes. Bonner, MC, Essa EA, Barry BW, Percutaneous absorption 4th Ed. Bronaugh and Maibach(eds.) Published by Taylor and Francis

*Vesicles under voltage. Bonner, MC, Barry BW, Percutaneous Penetration Enhancers, Smith and Maibach (eds.) Published by Taylor and Francis

*Electroporation as a Mode of Skin Penetration Enhancement. Bonner, MC, Barry BW, Enhancement in Drug Delivery, Touitou and Barry (eds.) CRC Press

*Combined Chemical and Electroporation Methods of Skin Penetration Enhancement. Bonner, MC, Barry BW, Enhancement in Drug Delivery, Touitou and Barry (eds.) CRC Press—————————————————————————National and International presentations

*Nov 2002 – Toronto, Canada. Chair of session ‘New Transdermal Therapies’ AAPS Annual Meeting,

*April 2004- La Grande Motte, France, Perspectives in Percutaneous Penetration International Conference ‘Skin sandwich method for examining shunt route permeation’

*August 2005 – Mount Holyoake, Massachusetts, USA, Gordon Research Conference ‘Barrier Function of Mammalian Skin’

*Dec 2005 Cambridge ‘Maximising the bioavailability of topically applied drugs’
May 2006- Zentiva Pharmaceuticals, Prague, Czech Republic ‘Particle characterisation and Drug Stability’

*May 2006 Guildford ‘Drug delivery to and through the skin’

*June 2006 Strathclyde ‘Sandwich method to assess shunt route contribution to skin penetration’

*July 2007 Invited presentation to Monash University, Melbourne