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HIV Paediatric Medicines Initiative

The IPI is looking to raise funds from generous individuals to support the HIV Paediatric Medicines Programme being run at the IPI.

The IPI in conjunction with its global partners (UNICEF, Innovation Team [Sweden], Antropologerne.com) is looking to develop simple, robust, flexible solutions to make HIV paediatric medicines more child friendly.

We are looking to raise money in order to fund a project to reformulate HIV medicines to make them child friendly.

You can donate in a number of ways:

Donation Online button

http://www.justgiving.com/giveHIVchildrenhope/

1) By cheque made out to
“University of Bradford – Project code DW44/10098”
Please post to Dr. Riddhi Shukla, Institute of Pharmaceutical Innovation, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK.
2) By bank transfer please quote Project code: DW44/10098
Bank Name:Lloyds TSB Bank PLc
Address:
Hustlergate Branch
45 Hustlergate
Bradford
BD1 1NT
West Yorkshire, UK
Bank Account Name: University of Bradford
Bank Account No: 04698283
Bank Account Code: 30-91-12
Iban No: GB61LOYD 3091 1204 6982 83
Swift Code: LOYDGB21016
3) By ringing Payzone with your debit/credit card details
+44 1274 233137
+44 1274 233138
Please quote Project code: DW44/10098

Thank you very much for your support

Project purpose:- The project aims to address the distressing fact that children with HIV/AIDS are still dying unnecessarily because of a lack of affordable “child-friendly” anti-retroviral drugs at appropriate doses in age appropriate presentations.

The Reality
WHO estimates 2.1 million children were living with HIV/AIDS at the end of 2007. Children are still dying due to the lack of affordable child friendly HIV drugs. Child deaths due to AIDS are estimated at ½ million, with approximately 1500 children becoming newly infected every day.

Not all anti-retroviral drugs in current WHO guidelines for children are currently made, or are available, in formulations suitable, palatable, acceptable or feasible for use in paediatric populations.

Current HIV medicines are not suitable due to a number of reasons:
• Currently in a liquid format – suspension or syrups
• Dosing is 6 to 8 times a day
• Orphanages (parents have died due to AIDS) are usually crowded – how can you make sure the child is receiving their dose?
• Stability issues – medicines need to be kept at 20°C, in Africa and Far East temperatures are around 30 °C to 40 °C
• In a country where average wage is $1 per day – how can you afford a $350 (£200) fridge?
• Electricity access in remote areas?
• How would you keep medication cool without a fridge?

Our solution will address the following issues currently faced by existing paediatric formulations:

*It will be palatable – taste better

*Provide a flexible dosing system that will be easy to administer

*Packaging can be adjusted to provide different dose combinations as required

*Require a once or twice daily administration

*Same dosing at both am and pm

*Provide control of therapeutic levels especially for narrow therapeutic window

*Stable product, shelf life 2-3 years

*Reduced storage/warehousing requirements

*Single manufacturing process

*Can easily be distributed (due to compact nature) through mobile and semi-mobile HIV/AIDS health clinics in order to provide greater reach of treatment

If you are interested in finding out more about this project please contact:
Dr. Riddhi Shukla
+ 44 1274 236196